Static IP Address Issue

I am running a Windows 2008 R2 server with two NICs. I have one NIC configured with a static IP address, and the other configured with a dynamic IP address. The way my ISP is set up, static addresses and dynamic addresses are on completely different subnets.  I have a virtual adapter set up on the card with the dynamic address.  I am now trying to set up a 2012 server in a VM. I have it networking through the adapter with the dynamic address.  It works perfectly as long as it, too, has a dynamic IP address.  However, I'd like to give the VM a static IP address.  As soon as I do that, it can't talk to the gateway.  So, I have two questions:

1. Does the VM's address have to be in the same subnet as the NIC it's going through?
2. Is there some way I can make this work?  If so, how?

Thanks!

Brad.